Cureus, Structural MRI Brain Alterations in Borderline Personality Disorder and Bipolar Disorder

Bipolar disorder (BD) and borderline personality disorder (BPD) share many behavioral features, such as periods of marked affective lability and instability. Although there is a symptomatic overlap, the two disorders may be differentiated based on longitudinal course, phenomenology, and treatment responsiveness. In addition, the emotional changes in BPD are generally influenced by interpersonal factors, whereas BD episodes tend to be more sustained. We performed a literature review on the structural MRI features of both disorders and compared the findings. There are differences in areas of white and gray matter volumes and thickness in BP and BPD. BPD primarily affects the fronto-limbic network, in particular, the amygdala, hippocampus, and orbitofrontal cortex, whereas BP affects both cortical and subcortical areas. There are a limited number of large studies, and many studies examined in this review did not adjust for confounding factors or motion artifacts, which limit the utility of current data.

Bipolar disorder can be hard to tell from depression due to their similar symptoms, except for mania in bipolar. Researchers had 80% accuracy in distinguishing bipolar disorder from depression using special MRI

Defining the neurocircuitry of borderline personality disorder: Functional neuroimaging approaches, Development and Psychopathology

Structural MRI Brain Alterations in Borderline Personality Disorder and Bipolar Disorder. - Abstract - Europe PMC

Amygdala Functional Connectivity in Young Women with Borderline Personality Disorder

Common and distinct patterns of grey matter alterations in borderline personality disorder and bipolar disorder: voxel-based meta-analysis, The British Journal of Psychiatry

Frontiers Structural Features Related to Affective Instability Correctly Classify Patients With Borderline Personality Disorder. A Supervised Machine Learning Approach

PDF) Structural MRI Brain Alterations in Borderline Personality Disorder and Bipolar Disorder

Structural brain abnormalities and suicidal behavior in borderline personality disorder. - Abstract - Europe PMC

Brain Sciences, Free Full-Text

A New Perspective on the Pathophysiology of Borderline Personality Disorder: A Model of the Role of Oxytocin

PDF] Neuroimaging and genetics of borderline personality disorder: a review.

Emotion dysregulation, impulsivity and anger rumination in borderline personality disorder: the role of amygdala and insula

Frontiers Neural Correlates of Social Inclusion in Borderline Personality Disorder

Cortical haemodynamic response during the verbal fluency task in patients with bipolar disorder and borderline personality disorder: a preliminary functional near-infrared spectroscopy study, BMC Psychiatry

GoodTherapy Therapy Changes Brains of People with Borderline Personality