Cells, Free Full-Text

Anthracyclines such as doxorubicin are widely used chemotherapy drugs. A common side effect of anthracycline therapy is cardiotoxicity, which can compromise heart function and lead to dilated cardiomyopathy and heart failure. Dexrazoxane and heart failure medications (i.e., beta blockers and drugs targeting the renin–angiotensin system) are prescribed for the primary prevention of cancer therapy-related cardiotoxicity and for the management of cardiac dysfunction and symptoms if they arise during chemotherapy. However, there is a clear need for new therapies to combat the cardiotoxic effects of cancer drugs. Exercise is a cardioprotective stimulus that has recently been shown to improve heart function and prevent functional disability in breast cancer patients undergoing anthracycline chemotherapy. Evidence from preclinical studies supports the use of exercise training to prevent or attenuate the damaging effects of anthracyclines on the cardiovascular system. In this review, we summarise findings from experimental models which provide insight into cellular mechanisms by which exercise may protect the heart from anthracycline-mediated damage, and identify knowledge gaps that require further investigation. Improved understanding of the mechanisms by which exercise protects the heart from anthracyclines may lead to the development of novel therapies to treat cancer therapy-related cardiotoxicity.

IJMS, Free Full-Text

Sequencing of Circulating Cell-free DNA during Pregnancy

The dependence of cell-free protein synthesis in E. coli upon

Remote immune processes revealed by immune-derived circulating

Labile coat: reason for noninfectious cell-free varicella-zoster

Full-spectrum cell-free RAN for 6G systems: s

Remote immune processes revealed by immune-derived circulating

Advances and applications of cell-free systems for metabolic

Nucleic acid biomarkers of immune response and cell and tissue

Circulating Tumor Cells, Disease Progression, and Survival in

Cells, Free Full-Text

Experimental design of upsidedown, upside-up, and cell-free

MitoQuicLy: A high-throughput method for quantifying cell-free DNA

An integrated in vivo/in vitro framework to enhance cell-free