The Safety of High Dose Labetalol in the Pregnant Population

Hypertension in pregnancy is one of the leading causes of maternal mortality and rapid treatment is critical. Treatment of emergent hypertensive crises in pregnancy is limited to only three medications, one of which is labetalol. Current literature recommends a daily maximum intravenous labetalol dose of 300 mg per day. However, this maximum dose has not been studied in pregnancy where higher doses may be required.

LABETALOL HYDROCHLORIDE tablet, film coated

Safety of Amlodipine in Early Pregnancy Journal of the American Heart Association

Oral nifedipine versus intravenous labetalol for acute blood pressure control in hypertensive emergencies of pregnancy: a randomised trial - Raheem - 2012 - BJOG: An International Journal of Obstetrics & Gynaecology - Wiley Online Library

Labetalol: Uses, Side Effects, Dosage & Reviews

530: Revisiting the limits of labetalol in the pregnant population: a Trinity Health system analysis - American Journal of Obstetrics & Gynecology

Drugs for treatment of very high blood pressure during pregnancy - Duley, L - 2013

Relias Media

Chapter 10. Hypertension in women

Frontiers Pharmaceutical administration for severe hypertension during pregnancy: Network meta-analysis

Is It Safe To Take Propranolol During Pregnancy?

Frontiers Regulatory Considerations for the Mother, Fetus and Neonate in Fetal Pharmacology Modeling

Labetalol Hydrochloride Tablets, USP 100 mg, 200 mg and 300 mgRx only