Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond

Behavioral experiences can modulate neural networks through changes in synaptic morphology and number. In contrast, abnormal morphogenesis of dendritic spines is associated with cognitive impairment, as in Fragile X syndrome. Dendritic or synaptic protein synthesis could provide the specificity and speed necessary for spine morphogenesis. Here, we highlight locally translated proteins shown to affect synaptic morphology (e.g., Fragile X mental retardation protein).

Co-Translational Folding: A Novel Modulator of Local Protein

Altered mRNA transport, docking, and protein translation in

Fragile X mental retardation protein in intrahepatic

Remote Control of Gene Function by Local Translation: Cell

Fragile X Syndrome: Loss of Local mRNA Regulation Alters Synaptic

Synaptic Activity Controls Dendritic Spine Morphology by

Frontiers The Coordination of Local Translation, Membranous

Pten heterozygosity restores neuronal morphology in fragile X

Local Protein Synthesis and Spine Morphogenesis: Fragile X

Fragile X syndrome: From protein function to therapy - Bagni

Fragile X mental retardation protein controls ion channel