Calcium Signaling Pathways Mediating Synaptic Potentiation Triggered by Amyotrophic Lateral Sclerosis IgG in Motor Nerve Terminals
Por um escritor misterioso
Last updated 04 julho 2024
![Calcium Signaling Pathways Mediating Synaptic Potentiation Triggered by Amyotrophic Lateral Sclerosis IgG in Motor Nerve Terminals](https://www.jneurosci.org/content/jneuro/26/10/2661/F2.large.jpg)
Sporadic amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that affects particularly motoneurons. Several pieces of evidence suggested the involvement of autoimmune mechanisms mediated by antibodies in ALS. However, the significance of those antibodies in the disease and the underlying mechanisms are unknown. Here we showed that IgG purified from a group of sporadic ALS patients, but not familial ALS patients, specifically interact with the presynaptic membrane of motoneurons through an antigen–antibody interaction and modulated synaptic transmission. Immunoreactivity against nerve terminals showed strong correlation with synaptic modulation ability. In addition, several controls have ruled out the possibility for this synaptic modulation to be mediated through proteases or nonspecific effects. Effective IgG potentiated both spontaneous and asynchronous transmitter release. Application of pharmacological inhibitors suggested that activation of this increased release required a nonconstitutive Ca2+ influx through N-type (Cav2.2) channels and phospholipase C activity and that activation of IP3 and ryanodine receptors were necessary to both activate and sustain the increased release. Consistent with the notion that ALS is heterogeneous disorder, our results reveal that, in ∼50% of ALS patients, motor nerve terminals constitutes a target for autoimmune response.
![Calcium Signaling Pathways Mediating Synaptic Potentiation Triggered by Amyotrophic Lateral Sclerosis IgG in Motor Nerve Terminals](https://static.hindawi.com/articles/bmri/volume-2014/907545/figures/907545.fig.001.jpg)
Novel Molecular Biomarkers at the Blood-Brain Barrier in ALS
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Motoneuron Death Triggered by a Specific Pathway Downstream of Fas
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![Calcium Signaling Pathways Mediating Synaptic Potentiation Triggered by Amyotrophic Lateral Sclerosis IgG in Motor Nerve Terminals](https://journals.physiology.org/cms/10.1152/physrev.00006.2016/asset/images/medium/z9j0041627730006.jpeg)
The Inositol Trisphosphate/Calcium Signaling Pathway in Health and
![Calcium Signaling Pathways Mediating Synaptic Potentiation Triggered by Amyotrophic Lateral Sclerosis IgG in Motor Nerve Terminals](https://ars.els-cdn.com/content/image/1-s2.0-S030439401730544X-gr2.jpg)
The role of mitochondria in amyotrophic lateral sclerosis
![Calcium Signaling Pathways Mediating Synaptic Potentiation Triggered by Amyotrophic Lateral Sclerosis IgG in Motor Nerve Terminals](https://www.jneurosci.org/sites/default/files/highwire/jneuro/21/17.cover.gif)
Recruitment of the Mitochondrial-Dependent Apoptotic Pathway in
![Calcium Signaling Pathways Mediating Synaptic Potentiation Triggered by Amyotrophic Lateral Sclerosis IgG in Motor Nerve Terminals](https://rgd.mcw.edu/pathway/PW0001140/calcium-calcium-mediated%20signaling%20pathway/pwmap.png)
calcium/calcium-mediated signaling pathwayRat Genome Database
![Calcium Signaling Pathways Mediating Synaptic Potentiation Triggered by Amyotrophic Lateral Sclerosis IgG in Motor Nerve Terminals](https://www.frontiersin.org/files/MyHome%20Article%20Library/341325/341325_Thumb_400.jpg)
Frontiers Amyotrophic Lateral Sclerosis (ALS) and Adenosine
![Calcium Signaling Pathways Mediating Synaptic Potentiation Triggered by Amyotrophic Lateral Sclerosis IgG in Motor Nerve Terminals](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fs41573-023-00823-1/MediaObjects/41573_2023_823_Fig1_HTML.png)
Targeting synapse function and loss for treatment of
![Calcium Signaling Pathways Mediating Synaptic Potentiation Triggered by Amyotrophic Lateral Sclerosis IgG in Motor Nerve Terminals](https://media.springernature.com/m685/springer-static/image/art%3A10.1186%2Fs12974-016-0538-2/MediaObjects/12974_2016_538_Fig4_HTML.gif)
Complement activation at the motor end-plates in amyotrophic
![Calcium Signaling Pathways Mediating Synaptic Potentiation Triggered by Amyotrophic Lateral Sclerosis IgG in Motor Nerve Terminals](https://www.jneurosci.org/content/jneuro/26/10/2661/F6.large.jpg)
Calcium Signaling Pathways Mediating Synaptic Potentiation
![Calcium Signaling Pathways Mediating Synaptic Potentiation Triggered by Amyotrophic Lateral Sclerosis IgG in Motor Nerve Terminals](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fnrn3531/MediaObjects/41583_2013_Article_BFnrn3531_Fig1_HTML.jpg)
Nuclear calcium signalling in the regulation of brain function
![Calcium Signaling Pathways Mediating Synaptic Potentiation Triggered by Amyotrophic Lateral Sclerosis IgG in Motor Nerve Terminals](https://www.frontiersin.org/files/Articles/1201982/fnagi-15-1201982-HTML/image_m/fnagi-15-1201982-g001.jpg)
Frontiers Microglia in Alzheimer's disease: pathogenesis
![Calcium Signaling Pathways Mediating Synaptic Potentiation Triggered by Amyotrophic Lateral Sclerosis IgG in Motor Nerve Terminals](https://ars.els-cdn.com/content/image/1-s2.0-S0896627306007252-gr4.jpg)
ALS: A Disease of Motor Neurons and Their Nonneuronal Neighbors
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