Evolutionary analysis of endogenous intronic retroviruses in primates reveals an enrichment in transcription binding sites associated with key regulatory processes [PeerJ]
Por um escritor misterioso
Last updated 02 junho 2024
Background Endogenous retroviruses (ERVs) are the result of the integration of retroviruses into host DNA following germline infection. Endogenous retroviruses are made up of three main genes: gag, pol, and env, each of which encodes viral proteins that can be conserved or not. ERVs have been observed in a wide range of vertebrate genomes and their functions are associated with viral silencing and gene regulation. Results In this work, we studied the evolutionary history of endogenous retroviruses associated with five human genes (INPP5B, DET1, PSMA1, USH2A, and MACROD2), which are located within intron sections. To verify the retroviral origin of the candidates, several approaches were used to detect and locate ERV elements. Both orthologous and paralogous genes were identified by Ensembl and then analyzed for ERV presence using RetroTector. A phylogenetic tree was reconstructed to identify the minimum time point of ERV acquisition. From that search, we detected ERVs throughout the primate lineage and in some other groups. Also, we identified the minimum origin of the ERVs from the parvorder Catarrhini to the Homininae subfamily. Conclusions With the data collected, and by observing the transcription factors annotated inside ERVs, we propose that these elements play a relevant role in gene expression regulation and they probably possess important features for tumorigenesis control.
Multilayered control of exon acquisition permits the emergence of
Skipper analysis of eCLIP datasets enables sensitive detection of
Hijacking of transcriptional condensates by endogenous
Paleovirology of 'syncytins', retroviral env genes exapted for a
Genomic approaches to trace the history of human brain evolution
m6A RNA methylation regulates the fate of endogenous retroviruses
Genomic approaches to trace the history of human brain evolution
Transcriptional enhancers: from prediction to functional
Eduardo Tejera's research works Universidad de Las Américas
Regulatory evolution of innate immunity through co-option of
Viruses, Free Full-Text
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