Oxidative Stress: A Pathogenic Mechanism for Niemann-Pick Type C
Por um escritor misterioso
Last updated 30 maio 2024
Niemann-Pick type C (NPC) disease is a neurovisceral atypical lipid storage disorder involving the accumulation of cholesterol and other lipids in the late endocytic pathway. The pathogenic mechanism that links the accumulation of intracellular cholesterol with cell death in NPC disease in both the CNS and the liver is currently unknown. Oxidative stress has been observed in the livers and brains of NPC mice and in different NPC cellular models. Moreover, there is evidence of an elevation of oxidative stress markers in the serumof NPC patients. Recent evidence strongly suggests that mitochondrial dysfunction plays an important role in NPC pathogenesis and that mitochondria could be a significant source of oxidative stress in this disease. In this context, the accumulation of vitamin E in the late endosomal/lysosomal compartments in NPC could lead to a potential decrease of its bioavailability and could be another possible cause of oxidative damage. Another possible source of reactive species in NPC is the diminished activity of different antioxidant enzymes. Moreover, because NPC is mainly caused by the accumulation of free cholesterol, oxidized cholesterol derivatives produced by oxidative stress may contribute to the pathogenesis of the disease.
Sphingolipid metabolism , Sit 4 p and TORC 1 in the yeast model of
IJMS, Free Full-Text
Frontiers The Role of Oxidative Stress and Natural Antioxidants
Investigation of Brain Iron in Niemann-Pick Type C: A 7T
Lysosomal and Mitochondrial Liaisons in Niemann-Pick Disease
Pathological roles of the VEGF/SphK pathway in Niemann–Pick type C
Reactive Oxygen Species and Oxidative Stress in the Pathogenesis
Cytokine profile and cholesterol levels in patients with Niemann
Unbiased yeast screens identify cellular pathways affected in
Niemann-Pick type C disease is associated with mtDNA
Investigation of Brain Iron in Niemann-Pick Type C: A 7T
Imaging of neuroinflammation in adult Niemann-Pick type C disease
Recomendado para você
-
Niemann-Pick disease type C: Video & Anatomy30 maio 2024
-
A new regulatory mechanism of STARD1 in Niemann-Pick disease type C (NPC), discovered30 maio 2024
-
Miglustat in Niemann-Pick disease type C patients: a review, Orphanet Journal of Rare Diseases30 maio 2024
-
PDF] Oxidative Stress: A Pathogenic Mechanism for Niemann-Pick Type C Disease30 maio 2024
-
Parents of twins with Niemann-Pick find a treatment30 maio 2024
-
Niemann–Pick disease - Wikipedia30 maio 2024
-
Niemann Pick disease30 maio 2024
-
Laboratory diagnosis of Niemann–Pick disease type C: The filipin30 maio 2024
-
Niemann-Pick Disease - Types, Causes, Symptoms, Diagnosis & Treatment30 maio 2024
-
White and gray matter alterations in adults with Niemann-Pick30 maio 2024
você pode gostar
-
Nakamura Beats Esipenko Who Blunders a Game in Round 2 of the FIDE30 maio 2024
-
Classic 'Tom and Jerry' Coming to Netflix US in June 2023 - What's30 maio 2024
-
Demon Slayer O Filme: Comboio Infinito - Análise30 maio 2024
-
Hell's Tavern30 maio 2024
-
Nintendo DS Sonic Classic Collection Video Games30 maio 2024
-
beckarnley-104-2075, Engine Mount30 maio 2024
-
Lettering merry christmas em português brasileiro com estrela cadente tradução feliz natal30 maio 2024
-
Game Used Colorado Avalanche Pro Stock Bauer Mach Glove & Blocker Regular Miner30 maio 2024
-
Media Factory, Hachi-nan tte, Sore wa Nai deshou!30 maio 2024
-
Painting Wall Decoration Sonic Sprite From the Video Game30 maio 2024