A new regulatory mechanism of STARD1 in Niemann-Pick disease type C (NPC), discovered

Researchers from the group Mitochondrial regulation of cell death and steatohepatitis have revealed a new role for acid ceramidase (ACDase) in experimental models and in patients with NPC through the regulation of STARD1 and its impact on mitochondrial function.

Elucidating the mechanism of cyclodextrins in the treatment of Niemann-Pick Disease Type C using crosslinked 2-hydroxypropyl-β-cyclodextrin

Mitochondrial GSH replenishment as a potential therapeutic approach for Niemann Pick type C disease - ScienceDirect

A human iPSC-derived inducible neuronal model of Niemann-Pick disease, type C1, BMC Biology

The Steroidogenic Acute Regulatory Protein (StAR)

IJMS, Free Full-Text

Mitochondrial function and regulation of macrophage sterol metabolism and inflammatory responses

UPR analysis in NPC mice cerebellum. a NPC and wildtype (WT) mice were

Mitochondrial Cholesterol in Alzheimer's Disease and Niemann–Pick Type C Disease

Intracellular Cholesterol Transport Arteriosclerosis, Thrombosis, and Vascular Biology