GPC2-CAR T cells tuned for low antigen density mediate potent

Pediatric cancers often mimic fetal tissues and express proteins normally silenced postnatally that could serve as immune targets. We developed T cell…

Full article: B7-H3-targeted CAR-T cell therapy for solid tumors

JCM, Free Full-Text

Mechanisms and strategies for safe chimeric antigen receptor T‐cell activity control - Stock - 2023 - International Journal of Cancer - Wiley Online Library

Strategies to enhance CAR-T persistence, Biomarker Research

GD2-CART01 for Relapsed or Refractory High-Risk Neuroblastoma

CD276-CAR T cells and Dual-CAR T cells targeting CD276/FGFR4 promote rhabdomyosarcoma clearance in orthotopic mouse models, Journal of Experimental & Clinical Cancer Research

BiCisCAR T cells targeting both GPC2 and CD276 show potent NB

Development of GPC2-directed chimeric antigen receptors using mRNA for pediatric brain tumors. - Abstract - Europe PMC

JCI - An optimized bicistronic chimeric antigen receptor against GPC2 or CD276 overcomes heterogeneous expression in neuroblastoma

Improving CAR-T immunotherapy: Overcoming the challenges of T cell exhaustion - eBioMedicine

PDF) Preclinical optimization of a GPC2-targeting CAR T-cell therapy for neuroblastoma

Present Status and Advances in Chimeric Antigen Receptor T Cell Therapy for Glioblastoma

Overcoming on-target, off-tumour toxicity of CAR T cell therapy for solid tumours

IJMS, Free Full-Text

Recent advances and discoveries in the mechanisms and functions of CAR T cells